After a median follow up of 60 months, disease free survival was 86 in the intermittent group and 87 order lasix cheap May be virilizing Usually larger than follicular cysts Multiple layers of granulosa cells Typical architectural patterns within cyst wall Call Exner bodies, trabecular, corded With or without invagination of granulosa cells into cyst wall Int J Gynecol Pathol 2020 Oct 16 Epub ahead of print Nuclear grooves may be inconspicuous in luteinized forms Extensive sampling may be required Pale to vacuolated cytoplasm Typical noncystic foci usually present Usually 1 layer of epithelial cells with serous, mucinous, clear cell or endometrioid morphology Negative for inhibin and calretinin, positive for EMA At least focally lined by endometrial type epithelium Surrounded by endometrial stroma with or without hemorrhage or hemosiderin laden macrophages within wall Considered physiologic Morphology identical to follicle cyst but measuring Denuded cyst without obvious lining or flattened lining No theca cells Occurs during pregnancy or puerperium Larger than follicular cyst median size 25 cm 1 to several layers of markedly luteinized granulosa cells and theca cells that are usually indistinguishable Variable nuclear atypia ranging from small round nuclei with single nucleolus to enlarged nuclei with focal marked pleomorphism, hyperchromasia and smudgy chromatin degenerative Absent or rare mitotic figures Secondary to elevated human chorionic gonadotropin hCG levels due to gestational trophoblastic disease, fetal hydrops, multiple gestations, ovarian hyperstimulation syndrome Hyperandrogenism in 15 Bilateral, multiple, thin walled follicle cysts with distinct granulosa and theca cells More extensive luteinization in theca cells compared with granulosa cells Markedly edematous ovarian stroma and groups of luteinized stromal cells between cysts Corpora lutea in ovarian hyperstimulation syndrome Undulating border and inner fibrous lining with a zone of small blood vessels with involution Int J Gynecol Pathol 2020 Oct 16 Epub ahead of print Markedly luteinized polygonal shaped granulosa cells with abundant eosinophilic cytoplasm Lined by serous type ciliated epithelium or nonciliated nonmucinous flat epithelium
