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EMA except in plexiform neurofibromas Can occur anywhere neurofibromas commonly involve scalp Soft masses bumps on or under skin internal or superficial itching mast cells release histamine pain and tingling in the affected area Severe bleeding sign of tumorgrowth disfiguration disabilitydeficits in movement clumsiness in hands, trouble walking incontinence an abnormalcurvature of the spine, if the tumor creates muscularimbalance or erodes bones of the spine Following symptoms may occur with genitourinary tract involvement rarely most common clinical manifestation Pelvic mass decreased bladder capacity or compliance as a focal mass or diffusebladder wall thickening in case of a plexiform neurofibroma often not identified, incorporates nerve, axons often present in lesion Seldom cystic Frequently multiple Widespread soft tissueinfiltration Tends to displace adnexa Affects individuals between 20 40 years of age Men and women are equally affected are thought to be congenital and occur earlier in life Loss of function of the tumor suppressor gene merlin schwannomin Direct geneticchange involving the NF2 gene on chromosome 22 Can occur spontaneously and biallelic inactivation of SMARCB1 spinalschwannomas how to get viagra prescription Appendix A Resources